Module 09. How to Perform an 18F FDG Viability Study-How to Perform an 18 F-FDG Viability Study (Slides)

How to Perform an 18 F-FDG Viability Study (Slides)

Pdf Summary

Module 9 of the "How to Perform Cardiac PET" series focuses on the 18F-FDG viability study. This study is performed in patients with ischemic heart failure, specifically those with LVEF ≤35% and potential coronary artery targets for revascularization in whom surgical risk is elevated. The goal of this module is to learn how to prepare patients for the 18F-FDG viability study, optimize 18F-FDG administration, acquire and process cardiac viability images, interpret the image patterns and findings, and create a viability study report.<br /><br />The module explains that 18F-FDG is used as a metabolic substrate by chronically ischemic cardiomyocytes, indicating viable but chronically ischemic myocardium. Areas of reduced perfusion with 18F-FDG uptake indicate hibernating myocardium. The module also discusses the technical aspects of performing the study, such as attenuation correction and image registration.<br /><br />For patients with diabetes, standard protocols may not be as effective, and higher doses of insulin with close monitoring or a euglycemic clamp may be necessary to optimize myocardial glucose uptake.<br /><br />The module emphasizes the importance of combining perfusion and 18F-FDG data to generate perfusion-metabolism patterns indicative of viable versus non-viable myocardium. It provides guidelines for imaging parameters, interpretation, and reporting.<br /><br />Examples of case studies are included to illustrate the interpretation of findings and the potential for recovery of function or outcome benefit.<br /><br />Overall, this module provides a comprehensive guide to performing and interpreting the 18F-FDG viability study in patients with ischemic heart failure.

Keywords

18F-FDG viability study

ischemic heart failure

LVEF ≤35%

coronary artery targets

revascularization

cardiac viability images

hibernating myocardium

attenuation correction

diabetes

perfusion-metabolism patterns