Module 06. How to Perform a 82Rb Perfusion Study-How to Perform a 82Rb PET Myocardial Perfusion Study (Slides)

How to Perform a 82Rb PET Myocardial Perfusion Study (Slides)

Pdf Summary

In this document, Module 6 of the "How to Perform Cardiac PET" series focuses on conducting a 82Rb (rubidium) myocardial perfusion study using PET. The module starts with an overview of PET cameras and their components, including detectors and rings. It explains the difference between 2D ("Septa-in") and 3D ("Septa-out") PET scanners in terms of coincidences and sensitivity.<br /><br />The document then discusses the use of different crystal types in PET cameras, such as bismuth germanate (BGO), gadolinium oxyorthosilicate (GSO), and lutetium-based crystals (LSO, LYSO). It explains that GSO and lutetium-based crystals may be advantageous in high count rate situations after 82Rb infusion.<br /><br />PET quality control is addressed next, emphasizing the importance of acceptance testing and daily, weekly, and annual quality control scans. Attenuation correction, performed using transmission scans and patient-specific attenuation maps, is essential for cardiac PET imaging.<br /><br />The module also covers CT protocols for hybrid imaging, including attenuation correction using unenhanced CT scans and coronary artery calcium (CAC) and coronary CTA scans. It provides recommendations for CT acquisition and emphasizes the need for accurate registration between PET and CT images.<br /><br />Quantification of myocardial blood flow (MBF) is discussed as a way to improve diagnostic accuracy and risk stratification. The document highlights various technical factors that can affect MBF quantitative accuracy, such as spatial resolution, infusion characteristics, timing, image reconstruction parameters, and data analysis.<br /><br />The module concludes with case examples showcasing normal and abnormal rest-stress 82Rb PET images. It provides examples of misregistration of CT attenuation and emission scans, as well as the impact of motion correction on MBF quantification.<br /><br />Key references for further reading on the topic are provided at the end of the document.

Keywords

Module 6

82Rb myocardial perfusion study

PET cameras

crystal types

attenuation correction

CT protocols

quantification of myocardial blood flow

diagnostic accuracy

motion correction

key references