Module 06. How to Perform a 82Rb Perfusion Study-How to Perform a 82Rb PET Myocardial Perfusion Study (Slides)

How to Perform a 82Rb PET Myocardial Perfusion Study (Slides)

Pdf Summary

This document is part 4 of a series on how to perform cardiac PET (Positron Emission Tomography) and focuses on the specific procedure for conducting a 82Rb (Rubidium) myocardial perfusion study. The module begins by listing the learning objectives, which include patient preparation, optimizing rubidium-82 injections, and acquiring and processing cardiac PET images.<br /><br />The document explains that dedicated PET cameras consist of rings of small detectors that produce tomographic slices of data. Different camera setups, such as 2D and 3D scanners, are discussed, with 3D scanners allowing for greater sensitivity but also increased scatter and count rate.<br /><br />The use of different crystal types, such as bismuth germanate, gadolinium oxyorthosilicate, and lutetium-based crystals, is explained. GSO and lutetium-based crystals are advantageous for high count rates associated with 82Rb scans.<br /><br />Quality control measures for PET cameras are described, including acceptance testing, daily QC scans, and periodic accuracy assessments of attenuation correction and image quality.<br /><br />The importance of attenuation correction is emphasized, and two techniques for transmission scans are discussed, involving either a line source or patient-specific attenuation maps. CT quality control is also highlighted, with a focus on calibration and field uniformity.<br /><br />The document provides a detailed 82Rb protocol, which includes patient preparation, elution of 82Rb from a generator, scout and CTAC scans, and image acquisition and reconstruction techniques.<br /><br />Additional information is given on CT protocols for hybrid imaging, including unenhanced and enhanced scans for attenuation correction, coronary artery calcium and coronary CT angiography.<br /><br />The section on quantifying myocardial blood flow (MBF) explains the benefits of quantitative analysis, such as improved diagnostic accuracy and risk stratification. Technical factors that affect MBF quantitative accuracy, such as scanner characteristics, infusion techniques, CT acquisition, and image generation and analysis, are discussed.<br /><br />The summary of the document highlights the key points, including the use of GSO and lutetium-based crystals for reducing scatter, the importance of proper registration between PET and CT images, and the usefulness of quantitative MBF analysis for specific patient populations.<br /><br />Selected references for further reading are provided at the end of the document.

Keywords

cardiac PET

82Rb myocardial perfusion study

patient preparation

rubidium-82 injections

acquiring cardiac PET images

PET cameras

2D and 3D scanners

bismuth germanate

gadolinium oxyorthosilicate

lutetium-based crystals