Masterclass in Cardiac Amyloidosis: Disease Spectrum, Diagnosis and Management-Think Amyloid Inpatient Floors Poster

Think Amyloid Inpatient Floors Poster

Pdf Summary

This document discusses transthyretin cardiac amyloidosis (ATTR-CA), a highly prevalent and underdiagnosed cause of heart failure (HF). It provides a list of "clinical red flags" that can indicate ATTR-CA, including bilateral carpal tunnel syndrome, repeat HF admissions, worsening HF despite medication compliance, and autonomic dysfunction. The document also outlines the recommended order for diagnostic tests, which includes an ECG, echo with strain, ruling out light chain amyloidosis, a pyrophosphate (PYP) scan, and a cardiology clinic referral. It notes that a low voltage ECG and a positive PYP scan are highly specific indicators of ATTR-CA. The document emphasizes that ATTR-CA is more prevalent in elderly individuals and carries a 4% prevalence in African American populations with a specific mutation. It also suggests obtaining more resources on ATTR-CA.

Keywords

transthyretin cardiac amyloidosis

ATTR-CA

heart failure

clinical red flags

diagnostic tests

ECG

pyrophosphate scan

low voltage ECG

elderly prevalence

African American mutation