JNC: Feasibility of myocardial blood flow quantification to detect flow-limited coronary artery disease with a one-day rest/stress continuous rapid imaging protocol on cardiac-dedicated cadmium zinc telluride single photon emission computed tomography (Mar/Apr 2024)-Feasibility of myocardial blood flow quantification to detect flow-limited coronary artery disease with a one-day rest/stress continuous rapid imaging protocol on cardiac-dedicated cadmium zinc telluride single photon emission computed tomography

Feasibility of myocardial blood flow quantification to detect flow-limited coronary artery disease with a one-day rest/stress continuous rapid imaging protocol on cardiac-dedicated cadmium zinc telluride single photon emission computed tomography

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The study focused on the feasibility of using a one-day rest/stress continuous rapid imaging protocol for SPECT myocardial blood flow quantification to detect flow-limited coronary artery disease. The research compared this protocol with the intermittently sequential imaging protocol in 120 patients, finding that the continuous rapid imaging protocol significantly reduced the examination time while maintaining diagnostic accuracy using residual activity correction.<br /><br />The study demonstrated that with residual activity correction, both protocols showed comparable stress myocardial blood flow and myocardial flow reserve values, leading to comparable diagnostic performance for detecting flow-limited coronary artery disease. The continuous rapid imaging protocol was found to be about 6.2 times shorter than the intermittently sequential imaging protocol. However, slightly higher residual activity was noted in the continuous rapid imaging protocol.<br /><br />The results indicated that the continuous rapid imaging protocol with rest residual activity correction is feasible for reliable myocardial blood flow quantification, leading to enhanced patient comfort and shortened examination time. The study highlights the importance of correcting for residual activity to accurately interpret stress myocardial blood flow values.<br /><br />Further evaluation is suggested to assess the impact of extracardiac activity on regional myocardial blood flow and perfusion patterns. Prospective studies with larger sample sizes are recommended to validate the findings and explore the protocol's applicability in routine clinical settings. Ultimately, the study provides valuable insights into improving the efficiency and accuracy of myocardial blood flow quantification in diagnosing coronary artery disease using SPECT imaging protocols.

Keywords

SPECT myocardial blood flow quantification

coronary artery disease

continuous rapid imaging protocol

residual activity correction

diagnostic accuracy

myocardial flow reserve

patient comfort

examination time

extracardiac activity

perfusion patterns