Interpreting and Reporting F-18 PET MPI: Focus on Flurpiridaz Cases-Interpreting and Reporting F-18 PET MPI: A Focus on Flurpiridaz Cases

Video Transcription

Video Summary

The webinar hosted by the American Society of Nuclear Cardiology focused on the interpretation and reporting of F-18 PET and PI using fluperidaz cases. Dr. Maaz Al-Mallah and Dr. Penita Shirentaitawi co-chaired the session, which included experts like Dr. Tim Bateman, Dr. James Case, Dr. Rob DeKamp, Dr. Marcella DeCarli, and Dr. Prem Soman. The primary goal was to discuss acquisition protocols, interpretation, and the unique properties of F-18 cardiac PET perfusion tracers.<br /><br />Dr. Shirentaitawi highlighted the arrival of F-18 fluperidaz as an essential development in nuclear cardiology. This tracer offers improved diagnostic capabilities with its high first-pass extraction fraction, linearity with myocardial blood flow, and short positron range. These characteristics enhance image quality, sensitivity, and specificity in detecting epicardial coronary artery disease compared to SPECT MPI. Fluperidaz also facilitates regional radiopharmacy distribution due to its longer physical half-life.<br /><br />Despite its benefits, challenges include limited initial clinical experience, higher radiation doses, and potentially higher costs. Protocols require at least a 30-minute wait between rest and stress phases during pharmacologic stress testing, and at least a 60-minute wait in exercise protocols, which could affect workflow efficiency.<br /><br />Cases demonstrated fluperidaz's ability to reveal finer perfusion defects and revisable issues like apical thinning. Expert panelists underscored the importance of careful motion correction and registration during image acquisition to ensure accurate results. The session encouraged interaction through polls and questions, promising future educational opportunities from ASNC to support clinical implementation of the new tracer.

Keywords

American Society of Nuclear Cardiology

F-18 PET

fluperidaz

nuclear cardiology

cardiac perfusion tracers

Dr. Maaz Al-Mallah

Dr. Penita Shirentaitawi

image quality

coronary artery disease

radiopharmacy distribution

myocardial blood flow

motion correction

clinical implementation